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Towards a novel understanding of Alzheimer’s disease

Our correspondent’s highlights from the symposium are meant as a fair representation of the scientific content presented. The views and opinions expressed on this page do not necessarily reflect those of Lundbeck.

References

1 Szaruga M et al. Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions. Cell. 2017;170:443-56.e14.

2 Gatz M et al. Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry. 2006;63:168-74.

3 Escott-Price V, et al. Polygenic risk score analysis of pathologically confirmed Alzheimer's disease. Ann Neurol. 2017; 82: 311-4.

4 Leonenko G et al. Polygenic risk and hazard scores for Alzheimer's disease prediction Ann Clin Transl Neurol. 2019; 6: 456-65.

5 Sala Frigerio C et al. The major risk factors for Alzheimer’s disease: age, sex, and genes modulate the microglia response to Aβ Plaques. Cell Reports, 2019;27:1293.

6 De Strooper B and Karran E. The cellular phase of Alzheimer’s disease. Cell. 2016;164:603-15.

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