Break the vicious cycle of worsening migraine

Many people living with migraine are caught in a vicious cycle of increasing migraine days and severity despite taking more acute medications1, ultimately worsening their condition2. Breaking this cycle requires alternative approaches that focus on efficacious, fast and sustained prevention3 rather than relying solely on acute interventions, enabling people to take control of their migraines and plan for what matters most.

An underdiagnosed disease

More than 1.1 billion people worldwide live with migraine.4

More than 1.1 billion people are currently living with migraine around the world4 – a disabling disease with unpredictable attacks of pain and other symptoms that can have a devastating impact on a person’s wellbeing, preventing them from living life to the full.4
Despite its prevalence and associated burden, migraine is often overlooked and its impact underestimated by HCPs, society and the very people living with it, leading to underdiagnosis and undertreatment.4

The vicious cycle of worsening migraine

Without effective preventive therapies to control the disease, migraine progresses in severity and impact,4 bringing with it a greater risk of overuse of acute medication leading to medication overuse headache and additional challenges and burdens.5,6

New treatments are promising

As new anti-CGRP preventive therapies prove their efficacy beyond reductions in migraine frequency,7,8 it is time to adjust our expectations upwards and provide a new perspective on migraine prevention.4,9 Effective preventive migraine treatment aims to reduce the frequency, severity and duration of attacks, thereby reducing the personal and economic burdens of people highly impacted by migraine (AHS 2019).

What do HCPs think patients should expect from future migraine treatment?

At the Lundbeck booth during the IHC congress in Seoul in September 2023, we encouraged visiting HCPs to grab a pen and write on the walls of the booth by asking them to share their thoughts to the following question:

"What do you think people living with migraine should expect from migraine treatment in the future?"

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  1. Aurora SK, Brin MF. Headache 2017;57:109-25.
  2. Bigal ME, Lipton RB. Curr Pain Headache Rep. 2009;13:301–7.
  3. Sun-Edelstein C et al. CNS Drugs 2021;35:545-565.
  4. Agosti R. Headache 2018; 58 (Suppl 1): 17–32
  5. Ailani J. Practical Neurology 2020; May: 67–71. Available at:
  6. Alstadhaug KB et al. Pain Rep 2017; 2: e612
  7. American Headache Society. Headache 2019; 59: 1–18
  8. American Migraine Foundation. The timeline of a migraine attack. Available at:
  9. Bell CF et al. Clin Rheumatol 2021; 40: 581–590
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