Addressing adherence

Addressing adherence issues in depression management

Despite the fact that antidepressant therapy is essential for positive patient outcomes, many patients remain non-adherent to their prescribed treatment plan.1

Less than a third of patients with depression receive and take their medication appropriately1

In fact, almost half of outpatients who are prescribed an antidepressant discontinue treatment within the first month,1,2 with almost 70% discontinuing within 3 months, depending on the medication prescribed.1

What’s causing this?
The reasons for this potential non-adherence differ between patients. However, a number of factors could be contributing to a patient’s non-compliance with therapy, including:1

  • Treatment-related adverse events
  • Unawareness of the importance of adhering to treatment, even if they feel better
  • Cognitive symptoms, including difficulties with memory and concentration
  • Feelings of hopelessness
  • Greater focus on relieving somatic symptoms
  • Stigmas surrounding depression, particularly regarding weakness
  • Feelings that treatment is not deserved
  • Lack of reassurance
  • Lack of continuity of care
  • Complex treatment regimens
  • Cost of treatment
  • Dissatisfaction with treatment response
  • Chronic illness
  • Perceived lack of a friendly relationship with healthcare professional

How can you help?
Some healthcare professionals recommend addressing patients’ potential adherence difficulties through a collaborative approach to their care. Working together can help to reinforce a positive physician–patient relationship, and provide insights into the patient’s own priorities for treatment outcomes. This, in turn, can provide motivation for the patient to comply with treatment, in pursuit of change that is both helpful and important to them.3

Additionally, the provision of education regarding the importance of compliance in antidepressant treatment can improve patient adherence to therapy. One randomised, controlled, prospective study found that the administration of a monthly, mail-based education programme had a positive influence on patients’ compliance.4

Even the introduction into appointments of simple and specific educational messages about antidepressant treatment and adherence have been shown to enhance compliance with therapy, at least in primary care settings.5 Above all, it is essential to emphasise the importance of continuing with treatment to patients with depression, even after improvement or cessation of symptoms.

  1. Bucci KK et al. Strategies to improve medication adherence in patients with depression. Am J Health-Syst Pharm 2003; 60: 2601-2605.
  2. Whooley MA, Simon GE. Managing depression in medical outpatients. New England Journal of Medicine 2000; 343(26): 1942-1950.
  3. Culpepper L. Cognition in MDD: implications for primary care. In: Cognitive dysfunction in Major Depressive Disorder. Ed: McIntyre R, Cha D, 2015.
  4. Hoffman L et al. Impact of an antidepressant management program on medication adherence. Am J Manag Care 2003; 9(1): 70-80.
  5. Lin EHB et al. The role of the Primary care Physician in Patients’ Adherence to Antidepressant Therapy. Medical Care 1995; 33(1): 67-74.
Country selection
We are registering that you are located in Brazil - if that's correct then please continue to Progress in Mind Brazil
You are leaving Progress in Mind
Please confirm your email
We have just sent you an email, with a confirmation link.
Before you can gain full access - you need to confirm your email.
The information on this site is exclusively intented for health care professionals.
All the information included in the Website is related to products of the local market and, therefore, directed to health professionals legally authorized to prescribe or dispense medications with professional practice. The technical information of the drugs is provided merely informative, being the responsibility of the professionals authorized to prescribe drugs and decide, in each concrete case, the most appropriate treatment to the needs of the patient.
Register for access to Progress in Mind in your country